He called for "social harmony in South Sudan, where current tensions have already caused numerous victims and are threatening peaceful coexistence in that young state."
Thousands are believed to have died in violence divided along ethnic lines between the Nuer and Dinka tribes in the country, which seceded from Sudan in 2011 after decades of war.
He also called for talks to end the conflicts in Syria, Nigeria, the Democratic Republic of Congo and Iraq, and prayed for a "favorable outcome" to the peace process between Israelis and Palestinians.
"Wars shatter and hurt so many lives!" he said, saying their most vulnerable victims were children, elderly, battered women and the sick.
The thread running through the message was that individuals had a role in promoting peace, either with their neighbor or between nations.
The message of the birth of Jesus in Bethlehem was directed at "every man or woman who keeps watch through the night, who hopes for a better world, who cares for others while humbly seeking to do his or her duty," he said.
In addition to his relatively forward-looking calls for peace and tolerance, Pope Francis' advocacy against greed, which he aired in his address, has made him one of the most prominent voices against economic injustice.
Ahead of Christmas, Francis sent 2,000 envelopes containing transit and telephone cards to people living around the Vatican, so that the poor could spend Christmas celebrating or at least speaking with loved ones.
Al Jazeera and Reuters
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