As police removed the yellow tape that cordoned off the scene, protesters converged on the home's front yard.
"Another youth down by the hands of police," said Dex Dockett, 42, who lives nearby. "What could have been done different to de-escalate rather than escalate? They [police] come in with an us-against-them mentality. You've got to have the right kind of cops to engage in these types of neighborhoods."
Another neighborhood resident, Fred Price, was skeptical about Dotson's account that the suspect pointed a gun at officers before being mortally wounded.
"They provoked the situation," Price, 33, said. "Situations like this make us want to keep the police out of the neighborhood. They're shooting first, then asking questions."
Dotson said at a late Wednesday press conference some protesters threw bricks and glass bottles at officers, who used shields to protect themselves and then used tear gas to disperse the crowd.
Nine people were arrested on charges of impeding traffic and resisting arrest, police said.
A car and piles of furniture and other belongings had been set on fire in the streets near protests, according to a report by the St. Louis Post-Dispatch newspaper. St. Louis Alderman Antonio French posted on Twitter that a vacant house was burning.
Wednesday's shooting came on the first anniversary of the police shooting of another black man in St. Louis, Kajieme Powell. Activists were already in the area for a march protesting his shooting.
The shooting also came 10 days after the St. Louis area was inundated with protesters from around the country marking the one-year anniversary of the police killing of unarmed black teenager Michael Brown by a white police officer.
Brown's death on Aug. 9, 2014 helped spark a nationwide movement against what protesters say is a pattern of police violence against minorities.
Following Brown’s death, protests erupted over police killings of other black men and women across the United States — including in New York, Baltimore and Ohio. Some of those protests have turned violent.
Al Jazeera and wire services